منابع مشابه
Globalizations Avant la Lettre: A Comparative View of Isomorphization and Heteromorphization in an Inter-Connecting World
The academic world has undoubtedly become smaller in recent decades. Chinese-, Spanish-, English-, Arabic-, French-, Russian-, Germanand Italianspeaking academics, intellectuals, and feuilletonists discuss ‘the end of history’ or ‘the clash of civilizations.’We all seem driven by the cycles of boom and bust that govern the planetary intellectual marketplace. New concepts such as ‘modernization’...
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Monoclonal antibodies (mAbs) have established themselves as the leading biopharmaceutical therapeutic modality. The establishment of robust manufacturing platforms are key for antibody drug discovery efforts to seamlessly translate into clinical and commercial successes. Several drivers are influencing the design of mAb manufacturing processes. The advent of biosimilars is driving a desire to a...
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Compelling evidence indicates Type I CD20 immunotherapeutic mAbs promote targeted tumor cell elimination exclusively via immune effector functions, which can be exhausted/saturated. mAb dosing paradigms should therefore take into account the capacity of these cytotoxic mechanisms, leading to the conclusion that lower doses, given frequently, may be far more effective.
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Complement activation by mAbs can cause direct tumor cell lysis or enhance antibody-dependent cell-mediated cytotoxicity. However, tumor cells are protected from complement-mediated injury by membrane-bound complement regulatory proteins (mCRP) that are often expressed at elevated levels on tumor cells. Recent studies indicate that blocking or overwhelming the function of tumor cell mCRP might ...
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ژورنال
عنوان ژورنال: Maandblad Voor Accountancy en Bedrijfseconomie
سال: 1994
ISSN: 2543-1684,0924-6304
DOI: 10.5117/mab.68.20656